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Thase et al19 found that after 8 weeks of treatment, least squares mean differences between vilazodone and placebo for changes in HAMA total and HAMD-17 Anxiety/Somatization subscale scores were ?1.82 (95% confidence interval ?2.81 to ?0.83, P (95% confidence interval ?1.17 to ?0.32, Pfind more subgroup to analyze potential differences in treatment effects. Findings suggested larger mean improvements with vilazodone versus placebo in the anxious subgroup relative to the nonanxious subgroup (however, only 18% of pooled vilazodone subjects had nonanxious depression at baseline). This finding was ��somewhat unexpected��, as similar analyses with other antidepressants often have not found a difference or have found lower efficacy among patients with anxious depression.56,61 The authors concluded that these results might point to vilazodone having benefits in treating depression with ��prominent�� anxiety symptoms, and that due to the statistical limitations, selleck compound further research is warranted. Overall, Thase et al19 concluded that ��vilazodone tuclazepam may be effective in treating patients with major depressive disorder who exhibit somatic and/or psychic symptoms of anxiety��. In two recently reported placebo-controlled vilazodone RCTs, HAMA scores have been reported. In Mathews et al,14 there was no significant difference for vilazodone 20 mg/day or vilazodone 40 mg/day on HAMA scores compared to placebo. Change from baseline at week 10 ranged from ?7.4 (0.4) to ?7.5 (0.4) for the active treatments compared to placebo ?6.7 (0.4). Perhaps counterintuitively, citalopram 40 mg/day treatment ?7.9 (0.4) was associated with significant change in HAMA scores (P