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Table 1 Comorbidities of patients with pyogenic spondylodiscitis Serial computed tomography (CT) scan, magnetic resonance imaging and anteroposterior and lateral radiographs were performed immediately after surgery and at 3, 6, and 12 months after operation, and then yearly (Fig. 2). Neurological deficits were grouped according to Frankel classification. Postoperative care included brace usage for 3 to 6 months, based on follow-up imaging and laboratory test. Back pain was evaluated with the visual analogue scale (VAS, 0�C10). Statistical analysis was performed using Dipivefrine SPSS ver. 20 (SPSS Inc., Chicago, IL, USA). The univariate analysis of data was carried out by the Pearson chi�\square test for discrete variables, and the t�\test for the continuous ones. Fig. 2 (A) At the six months follow-up, lateral radiograph revealed no segmental kyphosis or hardware breakage. (B) At the 1 year follow-up, a computed tomography scan with sagittal reconstruction demonstrated signs of bony fusion between T3 and T4 (white arrow). ... Results At the mean follow-up time of 30.16 months (range, 24�C53 months), resolution of spinal infection was achieved in all patients (defined with the normalization of inflammatory markers, changes in imaging reads, and resolution of pain). The mean duration of intravenous antibiotic therapy was 2.11 months (range, 1�C11 months), while the mean duration of oral antibiotic therapy was 5.33 months CX-5461 (range, 1�C12 months). Solid fusion at CT scan was achieved at the 12-months follow-up in all patients. There was no relapse of infection at the lesion level in any of the patients during follow-up and no titanium implants were removed. The average VAS of back pain before surgery was 9.16��1.29 at the final follow-up improved to 1.38��2.03, which was statistically significant (pForskolin the final follow-up improved 1.27 grades. On admission, the mean erythrocyte sedimentation rate was 90.61 mm/hr (range, 39�C156 mm/hr) and CRP level was 14.32��7.9 mg/dL (range, 2.6�C25.7 mg/dL). The erythrocyte sedimentation rate and CRP level became normal within 3 months after surgery for all patients and at the final follow-up the mean CRP decreased to 0.5��0.33 mg/dL (p