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However, in many patients with CVCs and GNB, the source of infection is not related to catheters and removal of the indwelling device is unnecessary and might deprive severely ill patients of a needed vascular access. In this current study we aimed to determine predictors of CRBSI among cancer patients with CVC and GNB. These clinical and microbiological predictors will serve as helpful criteria that will guide clinicians at the bedside as to whether the CVC is to be removed or retained. We performed a retrospective study on cancer patients with GNB and a CVC in place from July 2005 to December 2006 at The University of Ceftiofur Texas M. D. Anderson Cancer Centre, an oncological hospital with 500 beds in Houston, Texas. The Institutional Review Board approved this study and waiver of informed consent was obtained. Blood cultures were processed using the BACTEC 9240 automated culturing system (Plus Aerobic/F bottles; BD Diagnostic Systems, Sparks, MD, Sunitinib nmr USA) and the Isolator 10 system (Wampole Laboratories, Cranbury, NJ, USA). We routinely performed paired quantitative blood cultures. The number of colony-forming units had been quantified from 10?mL of blood cultured on plates. Time to positivity was recorded for blood cultures taken from the CVC and peripherally. We compared patients with CRBSIs with those with non-CRBSIs in terms of: sex; signs of infection, such as fever, chills, hypotension, and local inflammation at the CVC site; clinical characteristics, such as neutropenia (defined as an absolute neutrophil count www.selleckchem.com/products/3-methyladenine.html We assessed concordance by contrasting the predictive probability calculated for each subject grouped into pairs (one with CRBSI and one with non-CRBSI) with the actual findings. When the predicted probability of CRBSI of the subject with CRBSI is higher than the probability of the subject with non-CRBSI we say that the pair is concordant. Conversely, if the predicted probability of CRBSI is lower for the subject who did have infection then we say that the pair is discordant. When the predicted probability is the same, the pair is tied.