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To follow-up, we conducted a study based on optimized parameters and expanded the duration of the study to at least 1 year after treatment. Fourteen patients with 20 biopsy-proven BCCs on trunk and extremities, 8�C35?mm in diameter, were treated. Each BCC received four consecutive PDL treatments at 3�C4 week intervals. A 4?mm margin of clinically normal skin was also treated. Standardized photography was performed prior to each treatment and follow up visit. Patients were asked to consent for standard excision or at least scouting biopsies after treatment completion. Complete clinical response was seen with 19 of 20 treated BCCs, regardless of size Alectinib in vivo and histologic subtype. One did not respond completely to therapy. All remaining 19 BCCs were followed between 12 and 21 months (median?=?18 months) after the last PDL treatment. Of these 19 BCCs, only one recurred at 17 months follow up. The remaining 18 BCCs did not find protocol show any clinical signs of residual or recurrent tumor at 12�C21 months follow-up. Overall, 90% (18/20 tumors) of treated BCCs in this study showed no clinical or histologic evidence of BCC more than 12 months after PDL treatment. Additionally, 18/19 (95%) BCCs less than or equal to 17?mm showed no evidence of residual or recurrent tumor clinically or on histology 12�C21 months post-laser treatment. PDL treatment of BCC represents a novel, quick, and relatively non-painful treatment that does not usually produce scar and may represent an alternative treatment for certain types of BCC in the appropriate clinical setting. This study confirms prior findings regarding the efficacy of PDL in the treatment Tryptophan synthase of BCC, with longer follow-up period. Lasers Surg. Med. 42:72�C78, 2011 ? 2011 Wiley-Liss, Inc. ""5037" "The CbrAB two-component system has been described in certain species of Pseudomonads as a global regulatory system required for the assimilation of several amino acids (e.g. histidine, proline or arginine) as carbon or carbon and nitrogen sources. In this work, we used global gene expression and phenotypic analyses to characterize the roles of the CbrAB system in Pseudomonas putida. Our results show that CbrB is involved in coordination with the nitrogen control system activator, NtrC, in the uptake and assimilation of several amino acids. In addition, CbrB affects other carbon utilization pathways and a number of apparently unrelated functions, such as chemotaxis, stress tolerance and biofilm development. Based on these new findings, we propose that CbrB is a high-ranked element in the regulatory hierarchy of P.?putida that directly or indirectly controls a variety of metabolic and behavioural traits required for adaptation to changing environmental conditions. Bacteria can colonize very different niches because they can adapt to changing environmental conditions by altering their metabolism, physiology and behaviour.