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The objectives of the study were: 1. To evaluate the 12-month outcomes of patients with screened-positive depression in terms of symptom severity, health-related quality of life (HRQOL) and service use; 2. To identify the factors affecting prognosis; 3. To compare the outcomes of depressed patients who have and have not been identified by the PCP. Methods A cross-sectional followed by a longitudinal cohort study was conducted (Fig. 1). Baseline recruitment of subjects occurred between October 2010 and January 2012. Longitudinal data collection occurred between October 2010 and January 2013. The study protocol and preliminary findings of the cross-sectional study have been previously published (2,6). diglyceride This paper focusses on the findings of the cohort study. Figure 1. Patient recruitment flowchart. Setting and subjects Doctors working in primary care clinics across Hong Kong were invited to collaborate as part of a practice-based research network. PCPs were initially LDN-193189 clinical trial identified using the mailing list of the Hong Kong College of Family Physicians. Reflecting the delivery of primary care in Hong Kong, participants consisted of clinicians working in private practice, government-funded primary care clinics of the Hong Kong Hospital Authority, and non-profit, non-governmental organizations. Details of our subject sampling and recruitment strategy have been previously reported (6). In summary, all consecutive, eligible patients presenting to the study doctor on one randomly allocated day each month over a 12-month recruitment period were approached in the waiting room to complete a baseline survey. Patients were excluded if they were A-1210477 supplier A research assistant was present to administer the survey to those with poor literacy or eyesight and to answer any queries. Doctors (who were blinded to the depression screening scores) were asked to document the patient��s presenting problem, their opinion on whether the patient had depression and their management if they had identified the patient as being depressed. All respondents were invited to participate in the 12-month longitudinal follow-up. Those who consented by providing their name and contact details were interviewed by telephone at 12, 26 and 52 weeks (Fig. 1). Study instruments Questions on socio-demography and co-morbidity were adapted from previously performed primary care patient surveys and were asked at baseline (7).