The Very Bizarre Sulfatase Storyline

""It is known that the levels of hormones secreted from the pituitary gland are increased by ultraviolet B (UVB) eye irradiation. The ovaries are affected by the hormones secreted from the pituitary gland. Therefore, we observed the influence of UVB eye irradiation on the ovaries. In this study, a 2.5?kJ/m2 dose of UVB irradiation was delivered by a sunlamp to the eye or the ear of C57BL/6j female mice. Five days after UVB irradiation, we removed the ovaries. The plasma levels of ��-melanocyte-stimulating hormone (��-MSH), adrenocorticotropic hormone (ACTH), and ��-endorphin were increased 24?h after UVB irradiation of either the eye or the ear. The amounts of ACTH and ��-MSH DAPT were decreased 5 days after UVB irradiation. However, the ��-endorphin level 5 days after UVB eye irradiation did not decrease. In addition, UVB eye irradiation increased the expression of dopa-positive cells, tyrosinase, and dopa decarboxylase, and also increased the immunoreactivity of melanocortin-1 receptor in the ovaries. The dopamine content in the plasma was also increased. These results suggest that the melanin and dopamine systems of the ovary are affected by UVB eye irradiation, and the synthesized dopamine is maintained at high Sulfatase levels as ��-endorphin. ""Background/Purpose: Trans-urocanic acid is isomerized to cis-urocanic acid (C-UCA) by ultraviolet radiation. C-UCA suppresses immunity in vitro and in vivo in animals; its effect on human skin is unknown. We sought to determine whether its topical application to normal skin suppresses induction of immunity to dinitrochlorobenzene (DNCB). Methods: Forty subjects applied C-UCA (0%, 0.02%, 0.2%, or 2%) for 17 days. A 40-mcg dose of DNCB was then applied to induce immunity. Subjects were challenged for immunity at 6-week Doxorubicin concentration follow-up by occluding doses of DNCB (0, 3.125, 6.25, or 12.5?mcg) on untreated normal skin. Induced immunity was measured by area of erythema and induration 2 and 4 days postchallenge. Results: No significant differences were found in incidence of sensitization by C-UCA concentration (P=.59). DNCB sensitization developed in all 10 subjects induced through 0% C-UCA (placebo); only 23 of 30 patients were sensitized through skin treated with C-UCA. Mean areas of erythema and induration induced through C-UCA-treated skin were less than those in controls (P