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pudibundus (25��, 8.1%?kg H2O/mOsm��103)>P. pandaliformis (2��, 9.2)>M. acanthurus (30��, 12.6)>P. pandaliformis (35��, 16.7)>D. pagei (7��, 60.4). Muscle slices submitted in vitro to a 30% osmotic challenge confirmed in vivo results. Thus, the estuarine/freshwater osmoregulators displayed a lower capacity to hold muscle tissue water than the marine osmoconformer, despite undergoing narrower variations in hemolymph osmolality. J. Exp. Zool. 313A:80�C94, 2010. ? 2009 Wiley-Liss, Inc. ""1. Atherosclerosis is commonly observed in obesity. Obese atherosclerosis-prone animals may be a promising tool for understanding the pathophysiology of obesity-associated atherosclerosis. However, most rat strains are resistant to atherosclerosis. selleck kinase inhibitor The aim of the present study was to assess the susceptibility of two obese hypertensive rat models, namely SHRSP.Z-Leprfa/IzmDmcr rats (SHRSP-fatty) and SHR.Cg-Leprcp/NDmcr rats (SHR-cp), to arterial lipid deposition, an initial stage of atherosclerosis, IOX1 by comparing these strains with non-obese stroke-prone spontaneously hypertensive rats (SHRSP). 2. Eight-week-old male SHRSP, SHRSP-fatty and SHR-cp were fed a high-fat and high-cholesterol diet containing 20% palm oil, 5% cholesterol and 2% cholic acid for 5?weeks. Bodyweight, blood pressure and fasting serum levels of total cholesterol and triglycerides were measured in 12-week-old rats. Oil red O staining was used to visualize lipid deposition in the mesenteric artery. 3. The bodyweight of 12-week-old SHRSP-fatty and SHR-cp was higher than that of SHRSP (P?diglyceride respectively; P?