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4. The results demonstrated that the proposed method exhibited excellent linear correlation with the regular T2 mapping with full sampling and achieved better image reconstruction and T2 mapping with respect to SNR and reconstruction artifacts than the selected reference acceleration techniques. The new method has also been applied for quantitative tracking of injected magnetically labeled breast cancer cells in the rat brain with acceleration factors of 1.8 and 3.0. The proposed technique can provide an effective approach for accelerated CHIR-99021 in vivo T2 quantification, especially for experiments with single-channel coil when parallel imaging is not applicable. Copyright ? 2010 John Wiley & Sons, Ltd. ""The retina is nourished by two distinct circulations: the retinal vessels within the inner retina and the choroidal vessels behind the neural retina. The outer nuclear layer and the inner and outer segments of the photoreceptors in between are avascular. The aim of this study was to determine whether arterial spin labeling MRI could provide sufficient resolution to differentiate between quantitative retinal blood flow (rBF) and choroidal blood flow (chBF), and whether this technique is sufficiently sensitive to detect vascular-specific blood flow (BF) changes modulated by anesthetics. Arterial spin labeling MRI was performed at www.selleckchem.com/products/Y-27632.html 42?��?42?��?400??m3 in the mouse retina at 7 T, and was used to investigate the effects of isoflurane and ketamine/xylazine anesthesia on rBF and chBF. MRI yielded unambiguous differentiation of rBF, chBF and the avascular Fleroxacin layer in between. Under isoflurane, chBF was 7.7?��?2.1?mL/g/min and rBF was 1.3?��?0.44?mL/g/min (mean?��?SD, n?=?7, p?