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All neonates diagnosed with late-onset CoNS sepsis, defined see more as at least one positive blood culture drawn after 72?h of age in the presence of signs of infection [4], were eligible for participation in the study. Persistent CoNS bacteraemia was defined as three or more consecutive positive blood cultures with the same CoNS species, at least 48?h apart, during a single septic episode. All blood samples for culture were obtained by peripheral venipunctures with a sterile technique after appropriate skin disinfection. The study was approved by the Ethics Committee of the University Hospital of Patras, and informed consent was obtained from the parents. Demographic data, including sex, gestational age, birthweight, and postnatal age at the onset of septic episode (defined as the time of the first positive blood culture), were recorded. The presence of known risk factors for CoNS sepsis [6�C9] was also noted. The clinical profile of the neonates was evaluated on the basis of clinical manifestations at the onset of the septic episode, which included temperature instability (rectal temperature of 37.5��C), respiratory deterioration (increased number of oxygen desaturations, increase in oxygen requirement, need for ventilatory support, and increased number TRIB1 of apnoeas), circulatory deterioration (hypotension and signs of peripheral hypoperfusion), and feeding intolerance (abdominal distension or significant aspiration of gastric residue that required a decrease of >20% or cessation of feeding MK-2206 manufacturer for at least 24?h). The duration of the septic episode was also noted. The minimum platelet count during the septic episode was recorded. A platelet count of