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Symptoms of asthma, rhinitis and eczema, plus residential exposure to dampness and moulds, were ascertained by parental questionnaires (n?=?46?051). Skin examination, skin prick tests (n?=?26?967) and hypertonic saline bronchial challenge (n?=?5713) were performed. In subsamples stratified by wheeze (n?=?1175), dust was sampled and analysed for house dust mite (HDM) allergens and endotoxin. Current exposure to dampness was more common for wheezy children (pooled odds ratio 1.58, 95% CI 1.40�C1.79) and was associated with greater symptom severity among wheezers, irrespective of atopy. A significant (P?Megestrol Acetate in damp homes (OR 1.16, 1.03�C1.32). HDM-allergen levels were higher in damp homes and were positively associated with HDM-sensitization, but not wheeze. A consistent association of dampness with respiratory and other symptoms was found in both affluent and non-affluent countries, among both atopic and non-atopic children. HDM exposure and sensitization may contribute, but the link seems to be related principally to non-atopic mechanisms. ""To click here cite this article: Hon KLE, Chan IH-S, Chow C-M, Wang SS, Lam CW-K, Ng P-C, Leung T-F. Specific IgE of common foods in Chinese children with eczema. Pediatric Allergy Immunology 2011: 22: 50�C53. Food atopy is important but inadequately studied among children with atopic dermatitis (AD). We evaluated whether any association existed between AD severity, quality of life, total IgE, UMI-77 in vitro eosinophil counts, and the number of food items sensitized. Specific IgE of ten common food items was measured for a group of consecutive AD patients (n?=?85) enrolled during a randomized trial and correlated the findings with eczema severity. Twenty-four patients (28%) were negative for any of the ten common food items. The most commonly sensitized foods were shrimp (54%), egg white (43%), wheat (42%), and peanut (41%). Atopy to beef as a protein and orange as a fruit were least common among the food items studied, even among patients positive for 8�C9 IgE items. Patients with severe AD (objective SCORAD?>?40) were more likely to be positive for at least one of the food items (Yates corrected p?=?0.024 for ��1 food-specific IgE in severe vs. moderate AD, OR 3.42 and 95% CI 1.15�C10.32); and for at least seven of the food items (p?=?0.001 for ��7 food-specific IgE vs. nil with OR 11.67 and 95% CI 2.29�C67.77), respectively. The Spearman coefficients between the number of positive food-specific IgE and total SCORAD, objective SCORAD, area of AD involvement, Children��s Dermatology Life Quality Index (CDLQI), total IgE levels, and eosinophil counts were 0.42 (p?
