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In adjusted analyses, compared with non-obese women without diabetes, obese women with diabetes were more likely to have stress urinary incontinence (odds ratio [OR] 3.67), overactive bladder (OR 2.97), anal incontinence (OR 2.09) or any pelvic floor disorders (OR 2.62).22 Obese women without diabetes had the next highest incidence of stress urinary incontinence (OR 2.62), overactive bladder (OR 2.93), anal incontinence (OR 1.45) or any pelvic floor disorder (OR 1.83). Assisting obese women with diabetes to lose weight through all appropriate strategies may improve both pelvic floor function and diabetic control. Weight is a modifiable factor, so weight reduction (surgical and non-surgical) may be an effective treatment for the management of urinary incontinence. In a prospective study of obese women with incontinence on a dietary weight loss programme, Subak?et al.23 reported a 50% reduction in incontinence Baf-A1 nmr frequency after only a 5% decrease in weight. Deitel?et al.24 reported a decrease in the incidence of urodynamic stress incontinence from 61% to 11% among a group of 138 women who lost 50% Resminostat or more of their excess body weight. A well-conducted study25 of dietary modification, exercise and anti-obesity drugs recruited 64 women with a target weight loss of 5�C10%: 42 (65%) achieved their target weight loss and had significant reductions in BMI and girth. Weight loss was associated with significant reduction in pad test loss (median difference = 19 g; 95% CI 13�C28;?PLumacaftor seen in measures of vesical pressure, magnitude of bladder pressure increases with coughing, bladder-to-urethra pressure transmission with cough, urethral axial mobility, number of incontinence episodes and the need to use absorbent pads. Duloxetine is a serotonin and noradrenaline (norepinephrine) reuptake inhibitor which has been approved for the treatment of stress incontinence. Viktrup and Yalcin27 reviewed the impact of pre-existing risk factors, including BMI, on the efficacy of duloxetine in the management of stress incontinence. Significant improvements in all outcome measures (incontinence quality of life, incontinence episode frequency and patient global impression of improvement) were observed for the duloxetine group compared with placebo, independent of BMI strata. Overweight women tended to have a greater increase in incontinence quality-of-life score than women with a BMI