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In this study, repeated dose administration of WSE to the extent of 2000?mg/kg/day for 28 days did not produce any organ atrophy, hypertrophy, and degenerative or infiltrative lesion. 3.4.4. Microscopic examination There was no treatment related histopathological findings in the acute group and satellite group. Similarly in the sub-acute group and satellite group no treatment related microscopic changes were Gemcitabine mouse observed. All findings observed were consistent with the normal background lesions in clinical normal rats of the age and strain used in this study. They were considered spontaneous and/or incidental in nature and unrelated to the treatment. Results from the present study suggest that administration of WSE at a dose of 2000?mg/kg/day to rats for 28 days has no adverse microscopic effects [Fig.?3, Fig.?4, Fig.?5, Fig.?6]. Fig.?3 Brain (H and E,?��400): Normal brain histologic structure, no signs of cell degeneration and necrosis/cell damage. Fig.?4 Heart: Normal archistructure of heart, with cardiac muscle and pericardium. No signs of degeneration and necrosis/inflammation or other changes. Fig.?5 Liver (H and E,?��400): Normal liver archistructure at high power, no hypostatic congestion at portal vein, no signs of tissue damage or malignancy. Fig.?6 Kidney: Normal tubular structure and glomerular structure in treated and control group. No signs of damage to tubules. 4.?Discussions Root powder of WS is being used in the Ayurvedic system of medicine since ages, and it is found to be safe. Pure alcoholic or hydro alcoholic CB-839 nmr extracts of WS are not mentioned in Ayurveda, and the content of phytochemicals in such extracts is higher compared to raw powder. Animal toxicity studies with such extracts help to calculate safe starting doses in humans. A sub-acute toxicity study with hydroalcoholic extract of WS showed no evidence of toxic effect or mortality in Wistar Succimer rats [7]. Similarly, hydro alcoholic extract of WS found to be safe in sub-acute toxicity study involving rats and mice [8]. However the content of Withaferin A in these hydro alcoholic extracts are not reported. Our experience with the extraction shows that hydro alcoholic extract will have