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Skewed variables are expressed as the median value (interquartile range). Between patients with TD and subjects with normal TT levels, the Student's t-test for unpaired measures or the Mann�CWhitney U-test was used to compare normally distributed and skewed continuous variables, respectively. Categorical variables were compared using the chi-squared test. Correlations between PWVc-f and clinical characteristics were evaluated by calculation of the Pearson correlation coefficient. RecBCD The unadjusted association between PWVc-f and total testosterone may have been confounded by clinical and biochemical parameters that are important determinants of large artery stiffness. Therefore, we applied a stepwise multivariable linear regression model in which total testosterone was considered as the main independent variable while PWVc-f was considered as dependent variable. Parameters that determine arterial elastic properties were also introduced in the model as independent variables (covariates). In particular, age, mean BP, height, BMI, fasting blood glucose, total cholesterol, high density lipoprotein, high sensitivity CRP, smoking status and use of statins and ACE inhibitors/ARBS were forced in the multivariable model as covariates. The influence of testosterone levels on the association between age and PWVc-f was examined by categorizing patients in subgroups according to (i) age decade (70?yrs) and (ii) presence/absence of TD. The influence of testosterone levels on the association between blood pressure and PWVc-f was examined Selleckchem Crenolanib by categorizing patients in subgroups according to (i) mean pressure quartile (108?mmHg) and (ii) presence/absence of TD. Significant differences between men with TD and subjects without TD across age and mean pressure categories were determined using the Student independent-samples t-test after checking for equality of variances using the Levene's test. Analysis of covariance was performed in order to detect Antidiabetic Compound Library cell line significant differences in PWVc-f between men with TD and subjects without TD after adjustment for confounders that were significantly different between men with TD and subjects without TD. Finally, a 2-way between-groups analysis of variance was conducted to explore the impact of age (or mean pressure) categories and TT categories on PWVc-f. Statistical significance was defined as P?