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Simultaneously, there was a clockwise rotation in the basal segment of heart with opposite rotation in the apical segment. Moreover, the direction of myocardial motion was also in opposite directions during systole and diastole. Regional LV velocity, strain, and strain rate measurements As illustrated in Figures 1 and ?and2,2, the velocity curves in the long and short axes were both composed of positive and negative waveform. The positive waveform represented movement toward the reference in systole. By contrast, the negative waveform represented the myocardium moving away from the reference in diastole. The strain curve was a negative waveform with a unimodal wave. The lazabemide myocardium shortened in systole and lengthened in diastole and returned to its OL at the end of diastole (myocardial L in end diastole which marked as zero in the curve). The strain rate curve showed a negative waveform in the systolic period and a positive waveform in diastolic period, which represented myocardial shortening in systole and lengthening in diastole, respectively. Figure 1 The velocity curve along the long axis to assess the myocardial mechanics of the left ventricle in rabbits at basal state. Figure 2 The velocity curve along the short axis to assess the myocardial mechanics of the left ventricle in rabbits at basal state. VVI of the left ventricle The VVI parameter of the LV in long Veliparib supplier and short axes is shown in Tables 1 ?2,2, respectively. The longitudinal velocity of LV decreased from basal to apical segments (P the peak strain and strain rate did not change significantly (P>0.05). In the posterior left ventricle, the peak systolic velocity in middle segment and peak diastolic velocity in basal and middle segments were significant higher than the other segments of interventricular septum (PDAPT velocity in anterior septal and anteroseptal was significantly higher than the lateral, posterior and inferior walls (P