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7.16%��1.5%, PUnoprostone in the IT. The 87.0% of patients in the CG and 70.8% of patients in IT experienced hypoglycemia. Total hypoglycemic events per patient during the observation period were 5.26��6.5 events in the CG and 2.58��2.3 events in the IT (P=0.004). Overall, the number of hypoglycemic events was significantly BGJ398 in vivo higher in the CG compared with the IT (P=0.002), and the difference in the mean number of hypoglycemic events between the two groups was consistent across the four time periods (P for interaction=0.674). At 12 weeks, however, hypoglycemic events per patient were significantly increased in the CG compared with those in the IT (P=0.007) (Fig. 2A). The number of patients who discontinued insulin use was higher in the IT compared with those in the CG (41.7% vs. 22.7%, P=0.010). However, no difference was detected in the daily insulin dose between the groups at follow-up (Table 2). The percentage of patients who were treated with insulin was decreased in both groups (CG vs. IT, 77.3% vs. 54.2% at baseline, P=0.210; 36.4% vs. 12.5% at 24 weeks, P=0.060). Fig. 2 The number of hypoglycemic events per patient at each time point and causes of hypoglycemia. (A) Episodes of hypoglycemia per patient were significantly lower in the intensive group (IT) compared with the control group (CG) (P=0.002), and the difference ... The cause of hypoglycemia was significantly different between the groups phosphatase inhibitor library (P=0.029) (Fig. 2B). Approximately half of all hypoglycemic episodes were preceded by meal-related events before breakfast in the CG. However, unexpected or more vigorous exercise than usual was the most common antecedent of hypoglycemia in the IT. At 24 weeks, hypoglycemia management skills, such as detection of hypoglycemia symptoms by SMBG, correct management with a snack, re-checking blood glucose levels after 15 minutes, and dose adjustment of insulin or oral medication by schedule, were assessed. The percentage of patients who adhered to hypoglycemia management, especially re-checking blood glucose and adjusting the dose of their medication, was significantly higher in the IT compared with the CG (Fig. 3). Fig. 3 Adherence to hypoglycemia management at 24 weeks.