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A: Wild type of H460 cells were incubated with rWnt2 or IgG control at a concentration of 200 ng/mL for 3 hours and then the ... Wnt2 stimulates tumor growth in vivo Ki67 was used as a proliferation indicator to probe whether Wnt2 expression level was associated with tumor growth activity in vivo. Consecutive sections of patients with NSCLC were stained with Ki67 and Wnt2 antibody (Figure 6). The results in Table 4 revealed that higher MMP23B Wnt2 IHC staining scores correlated with higher Ki67 labelling index scores (rs, 0.316; P www.selleckchem.com/products/pci-32765.html immunohistological images of Wnt2 and Ki67 correlative expression in consecutive sections from human NSCLC surgical specimens. Original magnification, 200 ��; ... Figure 7 Overexpression of Wnt2 in the tumor microenvironment enhances tumor progression in vivo. A total of 5 �� 106 pLV-Wnt2 or pLV-vector cells was injected s.c. into each mouse (A). The tumor size was measured every week (B); at the end of the experiments, ... Table 4 Statistical analysis of immunohistochemical results of Wnt2 and Ki67 labelling index in 264 human NSCLC surgical samples Discussion Wnt signaling pathway is a kind of highly conservative signal transduction pathway in the process of biological evolution. The Wnt proteins, consisting of a large family of secreted glycoproteins, play an essential role in normal development and organogenesis, including in embryonic Venetoclax solubility dmso development [19] and tissue repair [20]. The Wnt proteins have been identified to be key factors in the process of tumorigenesis [21]. As an important member of the WNT family, WNT2 has been reported as a protooncogene which has the ability to activate the WNT/��-catenin signalling pathway. The Wnt2 protein reported to be over-expressed in many types of tumors, such as gastrointestinal carcinoma [9], breast cancer [11], pleural mesothelioma [22] and pancreatic carcinoma [12]. Li Fu et al. [8] reported that Wnt2(+) cells could be detected in 42/51 (82.4%) of the primary oesophageal squamous cell carcinoma cases.