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This finding contradicts the high levels observed among PIH women in Kumasi, Ghana by Turpin et al.,[3] and the low level recorded by Islam et al.,[21] but agrees with the works of Wakatsuki et al.,[14] and Lima et al.,[22] who observed no changes in HDL-C levels among preeclamptic women compared with normal controls. The discrepancies recorded in the levels of HDL-C among our participants compared to earlier studies could be premised on the fact that whereas Turpin et al. studied women with PIH, Islam et al., included both Peptide bond preeclamptics and eclamptics in his case control study. The cause of the increased levels of LDL recorded among our participants remains unclear as no correlation existed between maternal BMI and LDL-C [Table 2]. However, studies conducted by Salameh and Mastrogiannis,[23] have associated increased LDL-C levels to elevated estrogen and progesterone levels in preeclampsia. Our findings from correlation studies [Table 3] confirmed suggestions that LDL, TC, and HDL may be involved in the endothelial damage associated with the pathogenesis of preeclampsia. Endothelial dysfunction, mostly associated with oxidation of LDL, leads to the formation of glomerular lesions and subsequently proteinuria, which is associated with preeclampsia as well as give an indication of its severity. Obesity and abnormal lipid levels, especially TG contribute to the development of preeclampsia, which is characterized by proteinuria and high blood pressure, through endothelial dysfunction.[22] VX-680 purchase When we controlled for age and other confounders through multivariate logistic regression analysis the preeclamptic participants were R406 cost obese (OR = 1.501; CI = 0.926�C2.106; P = 0.01) and had hypertriglyceridemia (OR = 5.026; CI = 0.794�C31.818; P =