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735). Conclusion: There is increase in the risk of development of GDM with increased levels of serum uric acid in the first trimester. Uric acid levels at Selleck AMD3100 Gestational diabetes mellitus, Hyperuricemia, Serum uric acid Introduction GDM is one of the most important complications during pregnancy which is associated with both maternal and fetal morbidity and mortality [1]. World Health Organization and American Diabetes Association define GDM as ��any degree of glucose intolerance with onset or first recognition during pregnancy�� [2]. The prevalence ranges between 1 and 14 % of all pregnancies [1]. But studies conducted in different parts of the country averages the incidence of GDM in Indian population to be 16.55% [3]. Highest frequency of GDM among Indian women necessitates early diagnosis of GDM using glucose tolerance tests between 24 and 28 week of gestational age, though reports claim that about 40 to 66% of women with GDM can be diagnosed even earlier during pregnancy [4,5]. But no tests available before this gestational Cilengitide age which can predict the development of GDM. Serum uric acid is associated with insulin resistance in nonpregnant women [6]. It has been proven that, higher uric acid levels correlates with insulin resistance in women with hypertensive disorders Tacedinaline in vivo of pregnancy and also higher levels of uric acid levels were noted at 24 to 28 weeks of gestation in women with GDM when compared to women without GDM [7,8]. Normally during pregnancy, the serum uric acid levels decreases significantly from 8th week of gestation up to 24 weeks due to increased glomerular filtration rate and decreased re absorption of uric acid from the renal tubules. In the first trimester, it likely approximates preconception uric acid level and elevated levels may identify women who are predisposed to metabolic syndrome with an increased risk of developing GDM. Using this concept, we aimed at a prospective analysis of association of first trimester elevated uric acid levels with the development of GDM. This would be useful in predicting GDM at an earlier gestational age, thereby aiding in appropriate management of the same to prevent maternal and fetal morbidity and mortality. Material and Methods This prospective observational clinical study was conducted in Mahatma Medical College and Research Institute, Pondicherry, India, a tertiary care center, between November 2010 and May 2012 after obtaining the Ethical Committee clearance. Pregnant women of gestational age
