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02 and 0.055, respectively. The nasal epithelial barrier function, as reflected by these NALF biomarkers, was positively influenced by probiotics and age, and negatively by environmental stressors such as pool chlorine. The risk of house dust mite (HDM) sensitization Fluvoxamine increased with decreasing log NALF CC16 concentration, whether expressed per liter (2.59, 95% CI: 1.15�C5.82, P?=?0.02), as a ratio to urea (1.98, 95% CI: 0.96�C4.06, P?=?0.06), or as a ratio to albumin (OR, 2.03, 95% CI: 1.10�C3.74, P?=?0.02). Children in the highest and intermediate tertiles of the NALF albumin/urea ratio were three times more likely to be sensitized to HDM than those in the lowest tertile (both P?=?0.04). Defects in the nasal epithelium barrier function of young children, as reflected by the concentrations of CC16 and albumin in NALF, are associated with environmental factors, including pool chlorine, and with increased risks of HDM sensitization. Pediatr Pulmonol. 2013; 48:571�C578. I-BET-762 chemical structure ? 2012 Wiley Periodicals, Inc. ""Rapid and reliable confirmatory sweat testing following a positive newborn screen (NBS) for cystic fibrosis (CF) is preferred to allow for early diagnosis and to decrease parental anxiety. The Cystic Fibrosis Foundation (CFF) recently recommended a quantity not sufficient (QNS) rate of ��10% in infants selleck chemical database review of infants referred to the core Minnesota CF Center or its affiliate site for confirmatory sweat testing was performed to compare the QNS rates for the two techniques. Associations between birthweight, age at test, race, and QNS rates were examined. Five hundred sixty-eight infants were referred for 616 sweat tests from March 2006 to January 2010. The mean age was 32.8 days at the initial sweat test. The GCT had a significantly higher QNS rate compared to the MSCS (15.4% vs. 2.1%, P?