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[9-13] In Japan, there have been some reports on large outbreaks of HUS, including those in Osaka in 1996 and Toyama in 2011,[14-16] but there have been no long-term studies on changes in the incidence or severity of sporadic cases of HUS in any region of Japan. To evaluate the frequency of onset and the severity of HUS, we performed a retrospective study of the epidemiological and clinical features of patients treated for HUS at Fukushima Medical University Hospital, Fukushima Red Cross Hospital, Some General Hospital, Ohara General Hospital, Hoshi Venetoclax price General Hospital, Shirakawa General Hospital, Jusendo General Hospital and Takeda General Hospital, in Fukushima Prefecture (Japan) in a 26 year period. We collected the medical records for 26 patients who were diagnosed with HUS between January 1987 and December 2012 at the Department of Pediatrics, Fukushima Medical University School of Medicine. These 26 patients included 12 patients (first group) who had been diagnosed with HUS between 1987 Enzalutamide and 1999 and 14 patients (second group) who had been diagnosed with HUS between 2000 and 2012. Furthermore, these children were divided into D + HUS (n?=?24) and D�CHUS (n?=?2) groups based on the presence of diarrhea. The D + HUS group was further subdivided into group A (patients requiring hemodialysis and/or peritoneal dialysis and/or continuous hemodiafiltration [CHDF]; n?=?11) and group B (patients not requiring dialysis; n?=?13). Dialysis was performed on both D�CHUS patients. The epidemiological and laboratory data, clinical features, pathological findings, treatment and prognosis were retrospectively investigated for each group. The study was performed at Fukushima Medical University Hospital and informed consent was obtained from all patients or their parents. Patients were considered positive for hematuria if microscopy showed five or more red blood cells per high-power field, and macrohematuria was diagnosed if the same number of red blood cells was visible with the naked eye. Proteinuria was evaluated on 24?h quantitative measurement. Nephrotic syndrome was defined as the presence of proteinuria (40?mg/m2 per h) and serum albumin Histone demethylase and fragmented erythrocytes. Estimated glomerular filtration rate (eGFR) was calculated using the method of Nagai et?al.[17] Data are expressed as mean �� SEM. Statistical analysis was performed on a Macintosh computer using StatView (Abacus Concepts, Berkeley, CA, USA). Several variables, which were clearly not normally distributed, were compared using non-parametric statistics such as Mann�CWhitney test. P