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Generally, these associations remained even after adjustment for maternal and early childhood socio-economic, educational and other potential confounders. Our findings were similar in the analyses TGF-beta inhibitor with the overall educational achievement regardless of whether the latter was modelled as a binary or a continuous outcome (proportion having reached a good level of overall achievement or the mean total FSP score). We found no clear evidence that any of the six areas of development would particularly drive these associations, as the effect estimates in these six areas were similar to the estimates of the effect on the overall achievement and consistent with one another. The observed association between the longer duration of breastfeeding and better educational achievement during the early years of school may be due to better cognitive and behavioural development in breastfed children, which has been shown in previous studies by our group (Sacker et?al. 2006; Heikkila et?al. 2011; Quigley et?al. 2012) as well as others (Ip et?al. 2007; Kramer et?al. 2008; Oddy et?al. 2010a). Previous research suggests that infant feeding could influence child development through many biological or psychosocial mechanisms. For example, increased intake of the extensive range of essential fatty acids, oligosaccharides and other components of breast milk is likely to lead to improved neurological diglyceride and cognitive development (Coppa et?al. 2004, 2006; McCann & Ames 2005). There is also evidence that babies who are not breastfed are more prone to infectious illnesses than breastfed babies (Ip et?al. 2007; Quigley et?al. 2007), which click here may have an adverse impact on their social and cognitive development. Furthermore, breastfeeding could lead to more mother�Cbaby interaction, thus improving the readiness and ability to learn and develop in a social setting (Britton et?al. 2006; Denham et?al. 2009). Overall, the association estimates in our analyses were modest in size. Breastfed children were 10�C16% more likely to have achieved a good overall level of development and the total FSP scores were, on average, 2�C3 points higher in breastfed children when compared to never breastfed children. The question for further research remains whether these small differences translate to differences in later educational, developmental or health outcomes. In our analyses, the strongest ��co-risk factors�� for the association between breastfeeding duration and having reached a good level of educational achievement were mother's age and education, which are indeed known predictors of child cognitive development and educational achievement. In the fully adjusted models, the effect estimates for the ascending categories of mother's age and education, respectively, ranged from 1.20 to 1.25 and from 1.05 to 1.19 (all P-values