Wizard That May Be Concerned About C646

Tuberculoma resolved in one more patients. At 18 months tuberculomas resolved completely in 50% of the patients (7 of 14) who initially had tuberculomas and in another 50% there was a significant decrease in the size of tuberculomas. Maximum recovery was seen in stage I with 47% at 6 months, 68% at 12 months and 78% at 18 months compared to overall 37% at 18 months in stage II. Three of the five patients in stage III died (60% mortality) and only one made full recovery. On correlating the worst CT characteristics-tuberculomas, basal exudates and hydrocephalus with sequelae at 6 months �C focal deficit, cognitive impairment, selleck chemicals llc and diplopia it was seen that basal exudates correlated with all the three neurological sequelae i.e.; with Etomidate focal deficit (P = 0.001), cognitive impairment (P = 0.011), and diplopia (P = 0.021). Hydrocephalus correlated well with cognitive impairment (P = 0.031) and tuberculoma correlated with none of these clinical characteristics. Discussion Tubercular meningitis is common in developing countries, with a high morbidity and mortality. The diagnosis of TBM is based mainly on clinical and laboratory findings, particularly in adults.[14] Tubercular meningitis in developing countries is more common in infants and children with an increasing incidence in adolescents and young adults. In populations with low prevalence of TB, most cases of TBM occur in adults, and HIV has definitely increased the risk in adults. In our study of 61 patients of brain tuberculosis on 32.80% patients were in clinical stage I, 59.00% were in clinical stage II and 8.2% were in clinical III of meningitis. Sixty seven percent of the patients presented with severe disease (stages II and III). Five patients were deeply comatose on admission with a GCS of selleck screening library the patients presented with severe disease, that is, stage II (50%) and stage III (39.47%). Our results were also matching with Mishra et al.[16] where 83% of patients presented with severe disease. Computed axial tomographic scanning with contrast and magnetic resonance imaging have brought most of the intracranial pathology visible to the naked eye[9] Abnormalities reported on CT scan done in stages II and III disease are hydrocephalus, infarcts, basal enhancement, and cerebral edema.[10] Normal study is reported in up to 20% of the cases. Abdul Majid et al.[15] reported abnormal CT findings in 73.52% patients as basal enhancement in 36%, hydrocephalus in 28%, tuberculomas in 52%, infarcts in 12.0%, cerebral edema in 8.0%, and more than 1 finding in 32.0% of the patients. Normal study was in 26.4%. All patients in stage I disease had abnormal CT findings in comparison to 50% of stage II and 83.3% of stage III disease. Thus, CT scan is a useful diagnostic tool even in very early stages of TBM.