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29/68, p?0.01). The comparative characteristics of enterococcal, oral streptococcal and group D streptococcal IE are summarized in Fig.?2 Cefaloridine and Table?2. Enterococcal IE were more common than oral and group D streptococcal IE in North America, where they accounted for 50.3% of the cases when pooling the three groups. In all four other meta-regions, the ranking was more conventional, with oral streptococci, enterococci and group D streptococci occurring in descending order (Fig.?2). Comparison of the three organism groups demonstrated the following characteristics of enterococcal IE. Enterococcal IE more often developed in relation to healthcare intervention and in elderly patients with co-morbid conditions, as exhibited by a higher proportion of patients with diabetes or receiving haemodialysis and by a higher Charlson index. Patients with enterococcal IE more often had a prior history of IE, a prosthetic valve or an implanted intracardiac device. The course of the disease did not differ significantly in terms of frequency and type of complications, although the time between first symptoms and admission was significantly shorter selleck compound in enterococcal IE, which may reflect a more aggressive course of the disease and/or a more rapid diagnosis of healthcare-associated cases. The 1-year mortality rate was significantly higher for enterococcal than for streptococcal IE (Table?2). The variables that were analysed as potential prognostic factors for enterococcal IE are listed in Table?3. After bivariable analysis, six variables were then selected for the age- and sex-adjusted multivariable model. selleck inhibitor Finally, three variables were identified as significantly and independently associated with 1-year mortality. These were heart failure (HR 2.43 vs. no heart failure, 95% CI 1.71��3.45, p?